Research progress in protein-based hydrogels for promotion of hemostasis and wound healing / 中华创伤杂志

Rapid and effective hemostasis and wound healing are essential for life saving and improved quality of life. At present, traditional materials for hemostasis and wound healing have limited effects, with limitations such as unsatisfactory tissue adhesion effect, immunogenicity, secondary damage and infection risk, so it is urgent to develop new and efficient materials. Protein-based hydrogels have attracted more and more attention in the field of hemostasis and wound healing because of their good biocompatibility, biodegradability, injectability, adjustable mechanical properties and wet bonding. The authors review the definition of protein-based hydrogels and the research progress in various protein-based hydrogels in promotion of hemostasis and wound healing, in order to provide a reference for the application of protein-based hydrogels in wound repair.

Systemic antibiotics increase microbiota pathogenicity and oral bone loss / 国际口腔科学杂志·英文版

Periodontitis is the most widespread oral disease and is closely related to the oral microbiota. The oral microbiota is adversely affected by some pharmacologic treatments. Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis, causing negative effects on the human body. Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed. In this research, mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss. The results demonstrated, for the first time, that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis. Moreover, the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue. Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier, decreased the pathogenicity of the oral microbiota, reversed the Th17/Treg imbalance in periodontal tissue, and alleviated alveolar bone loss. This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis. A Th17/Treg imbalance might be related to this relationship. Importantly, these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice.

Caries status of primary and permanent teeth among 6-year-old children in Sichuan province and their correlation / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To investigate caries status of primary and permanent teeth among 6-year-old children in Sichuan Province and correlation between caries of deciduous molars and first permanent molars.</p><p><b>METHODS</b>Referenced to the sampling programme of the third national epidemiological survey of oral health status, a total of 714 children aged 6 were randomly sampled in clusters including 3 urban sampling spots and 3 rural sampling spots, the correlation between caries of deciduous molars and first permanent molars was explored.</p><p><b>RESULTS</b>The prevalence rate of deciduous tooth caries of 6-year-old children in Sichuan province was 74.37%, the mean number of dmft of 6-year-old was 3.94 +/- 3.93, the filling rate was only 4.96%. The prevalence rate and mean dmft of deciduous tooth caries showed no significant difference between different area and gender (P>0.05), however, the children came from city showed significant higher filling rate than those from countryside (P<0.05). The first permanent molars erupted have 2.98% in caries, the filling rate was 7.69%. Caries of deciduous molars was the first permanent molars caries risk factors among 6-year-old children in Sichuan province [P=0.001, r=0.175, OR=5.756, 95%CI (1.733, 19.121)]. There was weak correlation between caries of deciduous molars and first permanent molars (P<0.001, r=0.194).</p><p><b>CONCLUSION</b>Caries status of primary among 6-year-old children in Sichuan Province are serious. Caries experience of deciduous molars may play an important role in predicting the first permanent molars caries in clinic and prevention.</p>